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Biography

Mahyar Nouri-Shirazi, D.V.M., Ph.D., is a Professor of Immunology in the Department of Medicine at the Charles E. Schmidt College of Medicine at Florida Atlantic University. Dr. Nouri-Shirazi is an immunologist with a keen interest in immunotherapy and vaccines. He has contributed to the field of cancer immunotherapy by designing dendritic cell (DC)-based vaccines for patients with cancer, as well as to the field of transplant immunology through pharmacologically modified DC-based vaccines for tolerance induction. His research lab has also studied the possibility of refining the immune response to vaccines in individuals with compromised immune systems using Toll-like receptor (TLR) agonists. Among his educational responsibilities, he teaches Immunology to M1 and M2 medical and graduate ÐÓ°ÉÖ±²¥¼ä, and he serves as the director of the M2 Pathophysiology and Therapeutics 4 course.

Education

• 1992 D.V.M., Tottori University, School of Veterinary Medicine, Japan
• 1996 Ph.D., Chiba University, School of Medicine, Japan

Work History

• 2024-present Interim Associate Dean of Faculty Affairs, Charles E. Schmidt College of Medicine, Florida Atlantic University
• 2017-present Professor, Charles E. Schmidt College of Medicine, Florida Atlantic University
• 2011-2017 Associate Professor, Charles E. Schmidt College of Medicine, Florida Atlantic University
• 2008-2011 Assistant Professor, Charles E. Schmidt College of Medicine, Florida Atlantic University
• 2008-2011 Affiliated Assistant Professor of Microbiology & Immunology, University of Miami Miller School of Medicine
• 2005-2008 Adjunct Assistant Professor, Baylor University, Texas
• 2001-2008 Assistant Professor, Texas A&M University System Health Science center, Baylor College of Dentistry, Texas
• 1998-2001 Senior Research Scientist Fellow, Baylor Institute for Immunology Research, Texas
• 1996-1998 Research Scientist, Bayer Pharmaceutical Ltd, Research Center Kyoto, Division of Autoimmunity. Kyoto, Japan
• 1994-1996 Research Scientist, Columbia University, College of Physician and Surgeons, Department of Microbiology. New York, NY

Scholarly Activity

Selected Peer-Reviewed Publications

• Czdari Lee, Imtisal Imran, Sara Thomas, and Mahyar Nouri-Shirazi. A comprehensive method for the phenotypical and functional characterization of recalled human memory B and T cells specific to vaccine antigens. Journal of Immunological Methods. 2024 February 527
• Nouri-Shirazi M, Guinet E. TLR3 and TLR7/8 agonists improve immunization outcome in nicotine exposed mice through different mechanisms. Immunology Letters. 2022 Jun; 246:18-26.
• Zhou J, Nouri-Shirazi M, Tang H, Shen Y, Zeng M. R848/TLR7-Mediated Stronger CD8+ T Immunity Is Dependent on DC-NK Cell Interactions. International Archives of Allergy and Immunology. 2022 Mar 9:1-16.
• Katz H, Victor L, Guinet E, Nouri-Shirazi M. Human T cells show plasticity for direct recognition of xenogeneic dendritic cells. Immunology Letters. 2022 August: 248: 90-95
• Nouri-Shirazi M, Tamjidi S, Nourishirazi E, and Elisabeth Guinet. Combination of TLR8 and TLR4 agonists reduces the degrading effects of nicotine on DC-NK mediated effector T cell generation. INTERNATIONAL IMMUNOPHARMACOLOGY 61 (2018) 54-63
• Nouri-Shirazi M, Tamjidi S, Nourishirazi E, and Elisabeth Guinet. TLR8 combined withTLR3 or TLR4 agonists enhances DC-NK driven effector Tc1 cells. IMMUNOLOGY LETTERS 193 (2018) 58-66
• Zeng M, Nourishirazi E, Guinet E, and Nouri-Shirazi M. Genetic background influences the cellular and humoral immune responses to vaccines. CLINICAL AND EXPERIMENTAL IMMUNOLOGY Volume: 186 Issue: 2 Pages 190–204 Nov 2016
• Nouri-Shirazi, C. Kahlden, P. Nishino, and E. Guinet. Nicotine Exposure Alters the mRNA Expression of Notch Ligands in Dendritic Cells and Their Response to Th1-/Th2-Promoting Stimuli. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81(2): 110-120 FEB 2015
• Nouri-Shirazi M and Guinet E. Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination. THE JOURNAL OF IMMUNOLOGY 188 (5): 2359-70 MAR 2012
• Kogiso M, Nishiyama A, Shinohara T, Nakamura M, Mizoguchi E, Misawa Y, Guinet E, Nouri-Shirazi M, Dorey CK, Henriksen RA, Shibata Y. Chitin particles induce size-dependent but carbohydrate-independent innate eosinophilia. JOURNAL OF LEUKOCYTE BIOLOGY 90 (1): 167-76 JUL 2011
• Zeng MH, Guinet E, Nouri-Shirazi M. Comparative analysis of dendritic cells and anti-CD3/CD8 expanded regulatory T cells for application in transplantation. TRANSPLANT IMMUNOLOGY 22 (1-2): 82-92 2009
• Zeng M, Guinet E, Nouri-Shirazi M. B7-1 and B7-2 differentially control peripheral homeostasis of CD4(+)CD25(+)Foxp3(+) regulatory T cells. TRANSPLANT IMMUNOLOGY 20 (3): 171-179 2009
• Nouri-Shirazi M, Zeng MH, Guinet E. Dendritic cells and anti-CD3/CD28 expand naturally occurring regulatory T cells with different magnitude and nature. AMERICAN JOURNAL OF TRANSPLANTATION 8: 418-418 2008
• Nouri-Shirazi M, Tinajero R, Guinet E. Nicotine alters the biological activities of developing mouse bone marrow-derived dendritic cells (DCs). IMMUNOLOGY LETTERS 109 (2): 155-164 APR 15 2007
• Nouri-Shirazi M, Guinet E. A possible mechanism linking cigarette smoke to higher incidence of respiratory infection and asthma. IMMUNOLOGY LETTERS 103 (2): 167-176 MAR 15 2006
• Guinet E, Yoshida K, Nouri-Shirazi M. Nicotinic environment affects the differentiation and functional maturation of monocytes derived dendritic cells (DCs). IMMUNOLOGY LETTERS 95 (1): 45-55 AUG 15 2004
• Nouri-Shirazi M, Guinet E. Evidence for the immunosuppressive role of nicotine on human dendritic cell functions. IMMUNOLOGY 109 (3): 365-373 JUL 2003
• Berard F, Blanco P, Davoust J, Neidhart-Berard E, Nouri-Shirazi M, Taquet N, Rimoldi D, Cerottini JC, Banchereau J, Palucka AK. Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells. JOURNAL OF EXPERIMENTAL MEDICINE 192 (11): 1535-1543 DEC 4 2000
• Nouri-Shirazi M, Banchereau J, Bell D, Burkeholder S, Kraus ET, Davoust J, Palucka KA. Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses. JOURNAL OF IMMUNOLOGY 165 (7): 3797-3803 OCT 1 2000
• Ye BH, Cattoretti G, Shen QO, Zhang JD, Hawe N, deWaard R, Leung C, Nouri-Shirazi M, Orazi A, Chaganti RSK, Rothman P, Stall AM, Pandolfi PP, DallaFavera R. The BCL-6 proto-oncogene controls germinal-center formation and Th2-type inflammation. NATURE GENETICS 16 (2): 161-170 JUN 1997
• Yamamoto H, Hatano M, Iitsuka Y, Nouri-Shirazi M, Yamamoto M, Tokuhisa T. Two forms of HOX11, a T cell leukemia oncogene, are expressed in fetal spleen but not in primary lymphocytes. MOLECULAR IMMUNOLOGY 32 (16): 1177-1182 NOV 1995

Honors and ÐÓ°ÉÖ±²¥¼ä

• 2024 Distinguished Mentor of the Year Award: Excellence in Undergraduate Research and Inquiry Mentorship, Florida Atlantic University
• 2022 Outstanding Problem-Based Learning (PBL) Facilitator Award, Charles E. Schmidt College of Medicine
• 2019 Outstanding Course Director Award, Charles E. Schmidt College of Medicine
• 2016 AAI Travel Award, International Congress of Immunology
• 2015 AAI Laboratory Travel Award, The American Association of Immunologists
• 2014 AAI Laboratory Travel Award, The American Association of Immunologists
• 2013 Outstanding Problem-Based Learning (PBL) Facilitator Award, Charles E. Schmidt College of Medicine
• 2012 Researcher Excellence Award, American Association for Laboratory Animal Science
• 2012 AAI Laboratory Travel Award, The American Association of Immunologists
• 2011 Dwight W. Warren Award for Excellence in Graduate Teaching, Florida Atlantic University- Charles E. Schmidt College of Medicine
• 2007 Basic Science Faculty Research Award, Texas A&M University Health Science Center-Baylor College of Dentistry

Research funding

• Principal Investigator: NIH-NIAID 1R03AI103750-01A1
• Principal Investigator: Georgia Aquarium180288
• Principal Investigator: Phillip Morris Inc,. USA
• Mentor: Natural Science Foundation of China (NSFC)
• Mentor: NIH-NIDCR K23 DE00-469-01
• Collaborator: NIH-NINDS 1R15NS066339
• Co-investigator: CaPCURE
• Senior Scientist: NIH-NIAID R01CA78846-01A1

Patent

• Inventor: US file patent number 60/159,903
• Inventor: US file patent number US10/110,553
• Inventor: US Provisional patent #61/596,919

Editorial and Professional Affiliations

• Member: American Association of Immunologists (AAI)
• Member: Society of Leucocyte Biology (SLB)
• Editorial Board: Frontiers Immunology Journal